Knockdown of radixin by RNA interference suppresses the growth of human pancreatic cancer cells in vitro and in vivo.

@article{Chen2012KnockdownOR,
  title={Knockdown of radixin by RNA interference suppresses the growth of human pancreatic cancer cells in vitro and in vivo.},
  author={Shu-Dong Chen and Mao-min Song and Zhi-qiang Zhong and Na Li and Pan Wang and Shi Dan Cheng and Ri-xing Bai and Hui-sheng Yuan},
  journal={Asian Pacific journal of cancer prevention : APJCP},
  year={2012},
  volume={13 3},
  pages={
          753-9
        }
}
Radixin, encoded by a gene on chromosome 11, plays important roles in cell motility, invasion and tumor progression. However, its function in pancreatic cancer remains elusive. In this study, radixin gene expression was suppressed with a lentivirus-mediated short-hairpin RNA (shRNA) method. We found that radixin shRNA caused down-regulation of radixin in PANC-1 cells, associated with inhibition of pancreatic cancer cell proliferation, survival, adhesion and invasive potential in vitro. When… CONTINUE READING

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