Knockdown of piRNA pathway proteins results in enhanced Semliki Forest virus production in mosquito cells

Abstract

The exogenous siRNA pathway is important in restricting arbovirus infection in mosquitoes. Less is known about the role of the PIWI-interacting RNA pathway, or piRNA pathway, in antiviral responses. Viral piRNA-like molecules have recently been described following infection of mosquitoes and derived cell lines with several arboviruses. The piRNA pathway has… (More)
DOI: 10.1099/vir.0.053850-0

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