Knockdown of phosphoethanolamine transmethylation enzymes decreases viability of Haemonchus contortus.

@article{Witola2016KnockdownOP,
  title={Knockdown of phosphoethanolamine transmethylation enzymes decreases viability of Haemonchus contortus.},
  author={W. Witola and Sheritta Cooks-Fagbodun and Adriana Reyes Ordonez and Kwame Matthews and D. Abugri and M. McHugh},
  journal={Veterinary parasitology},
  year={2016},
  volume={223},
  pages={
          1-6
        }
}
The phosphobase methylation pathway, in which phosphoethanolamine N-methyltransferases (PMTs) successively catalyze the methylation of phosphoethanolamine to phosphocholine, is essential in the free-living nematode Caenorhabditis elegans. Two PMT-encoding genes (HcPMT1 and HcPMT2) cloned from Haemonchus contortus have been shown, by in vitro assays, to possess enzymatic characteristics similar to those of C. elegans PMTs, but their physiological significance in H. contortus is yet to be… Expand
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