Knockdown of miR-210 decreases hypoxic glioma stem cells stemness and radioresistance.

  title={Knockdown of miR-210 decreases hypoxic glioma stem cells stemness and radioresistance.},
  author={Wei Yang and Jing Wei and Tiantian Guo and Yueming Shen and Fenju Liu},
  journal={Experimental cell research},
  volume={326 1},
Glioma contains abundant hypoxic regions which provide niches to promote the maintenance and expansion of glioma stem cells (GSCs), which are resistant to conventional therapies and responsible for recurrence. Given the fact that miR-210 plays a vital role in cellular adaption to hypoxia and in stem cell survival and stemness maintenance, strategies correcting the aberrantly expressed miR-210 might open up a new therapeutic avenue to hypoxia GSCs. In the present study, to explore the… CONTINUE READING
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