Knockdown of m-calpain increases survival of primary hippocampal neurons following NMDA excitotoxicity.

@article{Bevers2009KnockdownOM,
  title={Knockdown of m-calpain increases survival of primary hippocampal neurons following NMDA excitotoxicity.},
  author={Matthew B Bevers and Eric J Lawrence and Margaret A Maronski and Neasa Starr and Michael Amesquita and Robert William Neumar},
  journal={Journal of neurochemistry},
  year={2009},
  volume={108 5},
  pages={
          1237-50
        }
}
The calpain family of cysteine proteases has a well-established causal role in neuronal cell death following acute brain injury. However, the relative contribution of calpain isoforms to the various forms of injury has not been determined as available calpain inhibitors are not isoform-specific. In this study, we evaluated the relative role of m-calpain and mu-calpain in a primary hippocampal neuron model of NMDA-mediated excitotoxicity. Baseline mRNA expression for the catalytic subunit of m… CONTINUE READING

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