Knockdown of long non-coding RNA XIST exerts tumor-suppressive functions in human glioblastoma stem cells by up-regulating miR-152.

@article{Yao2015KnockdownOL,
  title={Knockdown of long non-coding RNA XIST exerts tumor-suppressive functions in human glioblastoma stem cells by up-regulating miR-152.},
  author={Yilong Yao and J. Ma and Y. Xue and P. Wang and Z. Li and J. Liu and Liangyu Chen and Z. Xi and H. Teng and Z. Wang and Y. Liu},
  journal={Cancer letters},
  year={2015},
  volume={359 1},
  pages={
          75-86
        }
}
  • Yilong Yao, J. Ma, +9 authors Y. Liu
  • Published 2015
  • Biology, Medicine
  • Cancer letters
  • Glioblastoma (GBM) is the most common and aggressive primary brain tumor. Great interest persists in useful therapeutic targets in GBM. Aberrant expression of long non-coding RNAs (lncRNAs) has been functionally associated with many cancers. Here, we elucidated the function and the possible molecular mechanisms of lncRNA XIST in human glioblastoma stem cells (GSCs). Our results proved that XIST expression was up-regulated in glioma tissues and GSCs. Functionally, knockdown of XIST exerted tumor… CONTINUE READING
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