Knockdown of lncRNA GHET1 inhibits osteosarcoma cells proliferation, invasion, migration and EMT in vitro and in vivo.

@article{Yang2018KnockdownOL,
  title={Knockdown of lncRNA GHET1 inhibits osteosarcoma cells proliferation, invasion, migration and EMT in vitro and in vivo.},
  author={Wei Yang and Zhiming Shan and X. Zhou and L. Peng and Chongyang Zhi and J. Chai and Hong-xing Liu and Junmei Yang and Z. Zhang},
  journal={Cancer biomarkers : section A of Disease markers},
  year={2018},
  volume={23 4},
  pages={
          589-601
        }
}
OBJECTIVE Osteosarcoma is the most common primary malignant skeleton tumor that derives from mesenchymal cells. Emerging evidences have identified the vital role of long non-coding RNAs (lncRNAs) in the development of osteosarcoma. In this study, we aimed to investigate the role of lncRNA gastric carcinoma highly expressed transcript 1 (GHET1) in osteosarcoma progression. METHODS The expression levels of relevant genes in clinical samples and cell lines were determined by quantitative real… Expand
12 Citations
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LncRNA AWPPH promotes osteosarcoma progression via activation of Wnt/β-catenin pathway through modulating miR-93-3p/FZD7 axis.
TLDR
Results indicated AWPPH levels were increased in OS tissues in contrast to paracancerous controls and up-regulation indicated a low survival rate in OS patients, and suggested AWPPh may be a prognostic biomarker and potential therapeutic target. Expand
Growth hormone receptor promotes osteosarcoma cell growth and metastases
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It is demonstrated that growth hormone receptor (GHR) is overexpressed in OS samples compared with osteofibrous dysplasia and knockdown of GHR inhibited tumor growth in vivo, indicating that GHR modulates cell proliferation and metastasis through the phosphoinositide 3‐kinase/AKT signaling pathway. Expand
Aberrant Expression of Gastric Carcinoma High Expressed Transcript 1 is a Diagnostic and Prognostic Biomarker in Human Cancer.
BACKGROUND Gastric carcinoma high expressed transcript 1 (GHET1), a long noncoding RNA (LncRNA), has been reported to be involved in tumor genesis and cancer progression. High GHET1 expression isExpand
Overexpression of LncRNA GHET1 predicts an unfavourable survival and clinical parameters of patients in various cancers
TLDR
The pooled results of this study indicated that high lncRNA GHET1 expression level was significantly associated with poor overall survival in human cancers and may serve as a promising biomarker for prognosis in Asians with cancers. Expand
Clinicopathological and Prognostic Value of Gastric Carcinoma Highly Expressed Transcript 1 in Cancer: A Meta-Analysis
TLDR
High lncRNA GHET1 expression can predict poor survival and pathological parameters of cancer patients and could serve as a new indicator in multiple cancers, according to a meta-analysis. Expand
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