Knockdown of integrin beta4-induced autophagic cell death associated with P53 in A549 lung adenocarcinoma cells.

@article{He2008KnockdownOI,
  title={Knockdown of integrin beta4-induced autophagic cell death associated with P53 in A549 lung adenocarcinoma cells.},
  author={Qiuxia He and Bin Huang and Jing Zhao and Yun Zhang and Shangli Zhang and Jun-ying Miao},
  journal={The FEBS journal},
  year={2008},
  volume={275 22},
  pages={5725-32}
}
Integrin beta4 is a tissue-specific protein, but its role in autophagy of lung adenocarcinoma cells is not clear. In this study, we used microtubule-associated protein 1 light chain 3 processing and acridine orange staining to reveal that knockdown of integrin beta4 by its specific siRNA induced autophagic cell death in A549 lung cancer cells. Next, we… CONTINUE READING