Knockdown of hMex-3A by small RNA interference suppresses cell proliferation and migration in human gastric cancer cells.

@article{Jiang2012KnockdownOH,
  title={Knockdown of hMex-3A by small RNA interference suppresses cell proliferation and migration in human gastric cancer cells.},
  author={Hong Jiang and Xuemei Zhang and Jinhong Luo and Chunyan Dong and Junli Xue and Wei Wei and Jingde Chen and Jun Zhou and Yong Gao and Changqing Yang},
  journal={Molecular medicine reports},
  year={2012},
  volume={6 3},
  pages={575-80}
}
RNA-binding proteins (RBPs) play essential roles in RNA metabolism, regulating RNA splicing, transport, surveillance, decay and translation. The aberrant expression of RBPs leads to gene expression alteration and frequently causes various diseases, such as cancer. In this study, we are the first to provide evidence that hMex-3A, a RBP that belongs to the human Mex-3 family with two K-homology RNA-binding domains, is involved in the… CONTINUE READING