Knockdown of ezrin causes intrahepatic cholestasis by the dysregulation of bile fluidity in the bile duct epithelium in mice.

@article{Hatano2015KnockdownOE,
  title={Knockdown of ezrin causes intrahepatic cholestasis by the dysregulation of bile fluidity in the bile duct epithelium in mice.},
  author={Ryo Hatano and Kaori Akiyama and Atsushi Tamura and Shigekuni Hosogi and Yoshinori Marunaka and Michael J Caplan and Yoshiyuki Ueno and Sachiko Tsukita and Shinji Asano},
  journal={Hepatology},
  year={2015},
  volume={61 5},
  pages={
          1660-71
        }
}
UNLABELLED Cholangiopathies share common features, including bile duct proliferation, periportal fibrosis, and intrahepatic cholestasis. Damage of biliary epithelium by autoimunne disorder, virus infection, toxic compounds, and developmental abnormalities causes severe progressive hepatic disorders responsible for high mortality. However, the etiologies of these cholestatic diseases remain unclear because useful models to study the pathogenic mechanisms are not available. In the present study… CONTINUE READING
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