Knockdown of endogenous SKIP gene enhanced insulin-induced glycogen synthesis signaling in differentiating C2C12 myoblasts.

Abstract

PI(3,4,5)P(3) produced by the activated PI3-kinase is a key lipid second messenger in cell signaling downstream of insulin. Skeletal muscle and kidney-enriched inositol phosphatase (SKIP) identified as a 5'-inositol phosphatase that hydrolyzes PI(3,4,5) P(3) to PI(3,4)P(2), negatively regulates the insulin-induced glycogen synthesis in skeletal muscle… (More)

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@article{Xiong2009KnockdownOE, title={Knockdown of endogenous SKIP gene enhanced insulin-induced glycogen synthesis signaling in differentiating C2C12 myoblasts.}, author={Qi Xiong and Chang-yan Deng and Jin Choul Chai and S. L. Jiang and Yuan-zhu Xiong and Feng-E. Li and Rong Zheng}, journal={BMB reports}, year={2009}, volume={42 2}, pages={119-24} }