Knockdown of desmin in zebrafish larvae affects interfilament spacing and mechanical properties of skeletal muscle

Abstract

Skeletal muscle was examined in zebrafish larvae in order to address questions related to the function of the intermediate filament protein desmin and its role in the pathogenesis of human desminopathy. A novel approach including mechanical and structural studies of 4-6-d-old larvae was applied. Morpholino antisense oligonucleotides were used to knock down… (More)
DOI: 10.1085/jgp.201210915

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