Knockdown of astrocyte elevated gene-1 inhibits proliferation and enhancing chemo-sensitivity to cisplatin or doxorubicin in neuroblastoma cells

@article{Liu2009KnockdownOA,
  title={Knockdown of astrocyte elevated gene-1 inhibits proliferation and enhancing chemo-sensitivity to cisplatin or doxorubicin in neuroblastoma cells},
  author={Hongmei Liu and Xianrang Song and Chun-xi Liu and Li Xie and Ling Wei and Ruopeng Sun},
  journal={Journal of Experimental & Clinical Cancer Research : CR},
  year={2009},
  volume={28},
  pages={19 - 19}
}
BACKGROUND Astrocyte elevated gene-1 (AEG-1) was originally characterized as a HIV-1-inducible gene in primary human fetal astrocyte. Recent studies highlight a potential role of AEG-1 in promoting tumor progression and metastasis. The aim of this study was to investigate if AEG-1 serves as a potential therapeutic target of human neuroblastoma. METHODS We employed RNA interference to reduce AEG-1 expression in human neuroblastoma cell lines and analyzed their phenotypic changes. RESULTS We… CONTINUE READING
35 Citations
17 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 35 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 17 references

- 1 , Aeg - 1

  • SG Lee, ZZ Su, L Emdad, D Sarkar, PB Fisher
  • 2005

Similar Papers

Loading similar papers…