Knockdown of arginase I restores NO signaling in the vasculature of old rats.

Abstract

Arginase, expressed in endothelial cells and upregulated in aging blood vessels, competes with NO synthase (NOS) for l-arginine, thus modulating vasoreactivity and attenuating NO signaling. Moreover, arginase inhibition restores endothelial NOS signaling and l-arginine responsiveness in old rat aorta. The arginase isoform responsible for modulating NOS… (More)

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@article{White2006KnockdownOA, title={Knockdown of arginase I restores NO signaling in the vasculature of old rats.}, author={Anthony R. White and Sungwoo Ryoo and Dechun Li and Hunter C. Champion and Jochen Steppan and Danming Wang and Daniel P Nyhan and Artin A. Shoukas and Joshua M Hare and Dan E. Berkowitz}, journal={Hypertension}, year={2006}, volume={47 2}, pages={245-51} }