Knockdown of acyl-CoA:diacylglycerol acyltransferase 2 with antisense oligonucleotide reduces VLDL TG and ApoB secretion in mice.

@article{Liu2008KnockdownOA,
  title={Knockdown of acyl-CoA:diacylglycerol acyltransferase 2 with antisense oligonucleotide reduces VLDL TG and ApoB secretion in mice.},
  author={Ying Liu and John S Millar and Debra A Cromley and Mark Graham and Rosanne M. Crooke and Jeffrey T. Billheimer and Daniel J. Rader},
  journal={Biochimica et biophysica acta},
  year={2008},
  volume={1781 3},
  pages={97-104}
}
Acyl-CoA:diacylglycerol acyltransferases (DGATs) are enzymes that catalyze the formation of triglyceride (TG) from acyl-CoA and diacylglycerol. Two DGATs have been identified which belong to two distinct gene families and both are ubiquitously expressed. DGAT2 knockout mice are lipopenic and die shortly after birth. In the current study, wild type mice were treated with increasing doses (25-60 mg/kg twice weekly) of a DGAT2 gene-specific antisense oligonucleotide (ASO). Treatment resulted in a… CONTINUE READING

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