Knockdown of Y‑box‑binding protein‑1 inhibits the malignant progression of HT‑29 colorectal adenocarcinoma cells by reversing epithelial‑mesenchymal transition.

@article{Yan2014KnockdownOY,
  title={Knockdown of Y‑box‑binding protein‑1 inhibits the malignant progression of HT‑29 colorectal adenocarcinoma cells by reversing epithelial‑mesenchymal transition.},
  author={Xue-bing Yan and Qing-chao Zhu and Hong-Qi Chen and Jia-yuan Peng and Hong-Lei Chao and Hang-xiang Du and Zhigang Wang and Zhi-ming Jin},
  journal={Molecular medicine reports},
  year={2014},
  volume={10 5},
  pages={
          2720-8
        }
}
Y‑box binding protein‑1 (YB‑1) has been identified as an oncoprotein in various malignancies. The aim of this study was to investigate the biological role of YB‑1 and its association with epithelial‑to‑mesenchymal transition (EMT) in colorectal cancer (CRC). The expression of YB‑1 and three EMT‑related proteins (E‑cadherin, N‑cadherin and vimentin) was analyzed in 80 CRC and matched normal tissue samples, by immunohistochemistry. The results indicated that the expression of YB‑1 was higher in… CONTINUE READING

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