Knockdown of TWIST1 enhances arsenic trioxide- and ionizing radiation-induced cell death in lung cancer cells by promoting mitochondrial dysfunction.

@article{Seo2014KnockdownOT,
  title={Knockdown of TWIST1 enhances arsenic trioxide- and ionizing radiation-induced cell death in lung cancer cells by promoting mitochondrial dysfunction.},
  author={Sung-Keum Seo and Jae-Hee Kim and Ha-na Choi and Tae-boo Choe and S I Hong and Jae-Youn Yi and Sang-Gu Hwang and Hyun-Gyu Lee and Yun-Han Lee and I. -S. Park},
  journal={Biochemical and biophysical research communications},
  year={2014},
  volume={449 4},
  pages={490-5}
}
TWIST1 is implicated in the process of epithelial mesenchymal transition, metastasis, stemness, and drug resistance in cancer cells, and therefore is a potential target for cancer therapy. In the present study, we found that knockdown of TWIST1 by small interfering RNA (siRNA) enhanced arsenic trioxide (ATO)- and ionizing radiation (IR)-induced cell death in non-small-cell lung cancer cells. Interestingly, intracellular reactive oxygen species levels were increased in cells treated with TWIST1… CONTINUE READING