Knockdown of RNA binding protein musashi-1 leads to tumor regression in vivo.

@article{Sureban2008KnockdownOR,
  title={Knockdown of RNA binding protein musashi-1 leads to tumor regression in vivo.},
  author={Sripathi M. Sureban and Randal J May and Robert J. George and Brian K. Dieckgraefe and Ping Liao and Satish Ramalingam and Kumar S. Bishnupuri and Gopalan Natarajan and Shrikant Anant and Courtney W. Houchen},
  journal={Gastroenterology},
  year={2008},
  volume={134 5},
  pages={1448-58}
}
BACKGROUND & AIMS In the gut, tumorigenesis is thought to arise from the stem cell population located near the base of intestinal and colonic crypts. The RNA binding protein musashi-1 (Msi-1) is a putative intestinal and progenitor/stem cell marker. Msi-1 expression is increased during rat brain development and in APC(min/+) mice tumors. This study examined a potential role of Msi-1 in tumorigenesis. METHODS Msi-1 small interfering RNA (siRNA) was administered as a liposomal preparation to… CONTINUE READING

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