Knockdown of PTHR1 in osteosarcoma cells decreases invasion and growth and increases tumor differentiation in vivo

Abstract

Osteosarcoma (OS) is the most common cancer of bone. Parathyroid hormone (PTH) regulates calcium homeostasis and bone development, while the paracrine/autocrine PTH-related protein (PTHrP) has central roles in endochondral bone formation and bone remodeling. Using a murine OS model, we found that OS cells express PTHrP and the common PTH/PTHrP receptor… (More)
DOI: 10.1038/onc.2014.217

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@article{Ho2015KnockdownOP, title={Knockdown of PTHR1 in osteosarcoma cells decreases invasion and growth and increases tumor differentiation in vivo}, author={Patricia W. M. Ho and Ankita Goradia and Megan R. Russell and Alistair M. Chalk and Kristi M Milley and Emma K. Baker and Janine A. Danks and John L. Slavin and Mannu K. Walia and Blessing Crimeen-Irwin and Ross A Dickins and Thomas J Martin and Carl R Walkley}, journal={Oncogene}, year={2015}, volume={34}, pages={2922-2933} }