Knockdown of PLCε inhibits inflammatory cytokine release via STAT3 phosphorylation in human bladder cancer cells

@article{Yang2015KnockdownOP,
  title={Knockdown of PLCε inhibits inflammatory cytokine release via STAT3 phosphorylation in human bladder cancer cells},
  author={Xue Yang and Liping Ou and Min Tang and Youxiang Wang and Xiaorong Wang and En-ni Chen and Jianjun Diao and Xiaohou Wu and Chun Li Luo},
  journal={Tumor Biology},
  year={2015},
  volume={36},
  pages={9723-9732}
}
Phospholipase Cε (PLCε) is a multifunctional enzyme implicated in inflammatory functions. There are limited data, however, on how PLCε can alter inflammatory cytokine by affecting downstream pathways. Recent studies suggest that inflammation is likely to have an important role in transitional cell carcinoma of bladder (TCCB) and cancer disease progression. Here, we showed that PLCε and p-STAT3 expression were both elevated in TCCB tissues compared to adjacent tissues, and the increase of PLC… CONTINUE READING

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