Knockdown of Mgat5 inhibits CD133+ human pulmonary adenocarcinoma cell growth in vitro and in vivo.

@article{Zhou2011KnockdownOM,
  title={Knockdown of Mgat5 inhibits CD133+ human pulmonary adenocarcinoma cell growth in vitro and in vivo.},
  author={Xuefeng Zhou and H Chen and Qilong Wang and Li Zhang and J Zhao},
  journal={Clinical and investigative medicine. Medecine clinique et experimentale},
  year={2011},
  volume={34 3},
  pages={E155-62}
}
PURPOSE In spite of many therapeutic advances, the prognosis of lung cancer remains poor. Therefore, understanding the molecular mechanisms underlying cancer progression, invasion and metastasis is needed. Accumulating evidence indicate that N-acetylglucosaminyltransferase V (Mgat5 or GnT-V) is involved in cancer development. The purpose of this study was to characterize the expression and function of Mgat5 in CD133+ pulmonary adenocarcinoma cells. METHODS CD133+ pulmonary adenocarcinoma… CONTINUE READING

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CD133(+) human pulmonary adenocarcinoma cells induce apoptosis of CD8(+) T cells by highly expressed galectin-3.

Clinical and investigative medicine. Medecine clinique et experimentale • 2010
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