Knock-in of the Oas1b(r) allele into a flavivirus-induced disease susceptible mouse generates the resistant phenotype.

@article{Scherbik2007KnockinOT,
  title={Knock-in of the Oas1b(r) allele into a flavivirus-induced disease susceptible mouse generates the resistant phenotype.},
  author={Svetlana V. Scherbik and Kerri S Kluetzman and Andrey A. Perelygin and Margo A Brinton},
  journal={Virology},
  year={2007},
  volume={368 2},
  pages={232-7}
}
Inheritance patterns in mice suggested that resistance to flavivirus-induced disease was conferred by a single autosomal dominant allele (Flv(r)). A positional cloning strategy followed by comparison of Flv interval gene sequences from congenic resistant C3H.PRI-Flv(r) and susceptible C3H/He mouse strains identified the 2'-5'-oligoadenylate synthetase 1b (Oas1b) gene as Flv. However, since these mouse strains differ by a 31 cM region, the possible involvement of differences in other linked… CONTINUE READING

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