Knock-in gain-of-function sodium channel mutation prolongs atrial action potentials and alters atrial vulnerability.

Abstract

BACKGROUND Patients with long QT syndrome (LQTS) are at increased risk not only for ventricular arrhythmias but also for atrial pathology including atrial fibrillation (AF). Some patients with "lone" AF carry Na(+)-channel mutations. OBJECTIVE The purpose of this study was to determine the mechanisms underlying atrial pathology in LQTS. METHODS In mice… (More)
DOI: 10.1016/j.hrthm.2010.08.016

Topics

Cite this paper

@article{Blana2010KnockinGS, title={Knock-in gain-of-function sodium channel mutation prolongs atrial action potentials and alters atrial vulnerability.}, author={Andreas Blana and Sven Kaese and Lisa Fortmueller and Sandra Laakmann and Dierk Damke and Kelly A van Bragt and Jens Eckstein and Ilaria Piccini and Uwe Kirchhefer and Stanley Nattel and G{\"{u}nter Breithardt and Peter Carmeliet and Edward E. Carmeliet and Ulrich Schotten and Sander Verheule and Paulus Kirchhof and Larissa Fabritz}, journal={Heart rhythm}, year={2010}, volume={7 12}, pages={1862-9} }