Knock-down of glutaminase 2 expression decreases glutathione, NADH, and sensitizes cervical cancer to ionizing radiation.

Abstract

Phosphate-activated mitochondrial glutaminase (GLS2) is suggested to be linked with elevated glutamine metabolism. It plays an important role in catalyzing the hydrolysis of glutamine to glutamate. The present study was to investigate the potent effect of GLS2 on radioresistance of cervical carcinoma. GLS2 was examined in 144 cases of human cervical cancer… (More)
DOI: 10.1016/j.bbamcr.2013.08.003

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Cite this paper

@article{Xiang2013KnockdownOG, title={Knock-down of glutaminase 2 expression decreases glutathione, NADH, and sensitizes cervical cancer to ionizing radiation.}, author={Lisha Xiang and Ganfeng Xie and Chen Liu and Jie Zhou and Jianfang Chen and Songtao Yu and Jianjun Li and Xueli Pang and Hang Shi and Houjie Liang}, journal={Biochimica et biophysica acta}, year={2013}, volume={1833 12}, pages={2996-3005} }