Knock-down of NDRG2 sensitizes cervical cancer Hela cells to cisplatin through suppressing Bcl-2 expression

@inproceedings{Liu2012KnockdownON,
  title={Knock-down of NDRG2 sensitizes cervical cancer Hela cells to cisplatin through suppressing Bcl-2 expression},
  author={Junye Liu and Le Yang and Jian Zhang and Jing Zhang and Yongbin Chen and Kang-chu Li and Yurong Li and Yan Li and Li-bo Yao and Guozhen Guo},
  booktitle={BMC Cancer},
  year={2012}
}
NDRG2, a member of N-Myc downstream regulated gene family, plays some roles in cellular stress, cell differentiation and tumor suppression. We have found that NDRG2 expression in cervical cancer Hela cells increases significantly upon stimulation with cisplatin, the most popular chemotherapeutic agent currently used for the treatment of advanced cervical cancer. This interesting phenomenon drove us to evaluate the role of NDRG2 in chemosensitivity of Hela cells. In the present study, RNA… CONTINUE READING

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