Knock-In Mouse Model of Dilated Cardiomyopathy Caused by Troponin Mutation

@article{Du2007KnockInMM,
  title={Knock-In Mouse Model of Dilated Cardiomyopathy Caused by Troponin Mutation},
  author={Cheng-Kun Du and S. Morimoto and K. Nishii and R. Minakami and M. Ohta and N. Tadano and Q. Lu and Y. Wang and D. Zhan and M. Mochizuki and S. Kita and Y. Miwa and F. Takahashi‐Yanaga and T. Iwamoto and I. Ohtsuki and T. Sasaguri},
  journal={Circulation Research},
  year={2007},
  volume={101},
  pages={185-194}
}
We created knock-in mice in which a deletion of 3 base pairs coding for K210 in cardiac troponin (cTn)T found in familial dilated cardiomyopathy patients was introduced into endogenous genes. Membrane-permeabilized cardiac muscle fibers from mutant mice showed significantly lower Ca2+ sensitivity in force generation than those from wild-type mice. Peak amplitude of Ca2+ transient in cardiomyocytes was increased in mutant mice, and maximum isometric force produced by intact cardiac muscle fibers… Expand
Investigation of a transgenic mouse model of familial dilated cardiomyopathy.
Inherited cardiomyopathies caused by troponin mutations
Familial dilated cardiomyopathy mutations uncouple troponin I phosphorylation from changes in myofibrillar Ca²⁺ sensitivity.
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