Klotho suppresses growth and invasion of colon cancer cells through inhibition of IGF1R-mediated PI3K/AKT pathway.

@article{Li2014KlothoSG,
  title={Klotho suppresses growth and invasion of colon cancer cells through inhibition of IGF1R-mediated PI3K/AKT pathway.},
  author={Xinxiang Li and Li-yong Huang and Jun-jie Peng and Lei Liang and De-bing Shi and Hong-Tu Zheng and Sanjun Cai},
  journal={International journal of oncology},
  year={2014},
  volume={45 2},
  pages={611-8}
}
Klotho (KL) was originally characterized as an aging suppressor gene, and has been identified as a tumor suppressor gene in a variety of cancers including colon cancer. However, the potential role and molecular events for KL in colon cancer remain unclear. The present study aimed to investigate the expression of KL in human colon cancer by immunohistochemistry, and to analyze the correlation between KL expression and clinicopathological characteristics of patients with colon cancer. Functional… CONTINUE READING
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