Klotho protein promotes adipocyte differentiation.

@article{Chihara2006KlothoPP,
  title={Klotho protein promotes adipocyte differentiation.},
  author={Yukana Chihara and Hiromi Rakugi and Kazuhiko Ishikawa and Masashi Ikushima and Yoshihiro Maekawa and Junsuke Ohta and Iwao Kida and Toshio Ogihara},
  journal={Endocrinology},
  year={2006},
  volume={147 8},
  pages={3835-42}
}
Mice with homozygous disruption of the klotho exhibit multiple age-related disorders and have barely detectable amounts of white adipose tissue. Although klotho expression in cultured adipocytes has been reported, little is known about its function in adipocytes. In the present study, we investigated the role of klotho on adipocyte differentiation. Adipocyte differentiation was induced by incubation of confluent 3T3-L1 cells with insulin, dexamethasone, and 1-methyl-3-isobutyl-xanthin. Klotho… CONTINUE READING

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