Klotho protein deficiency and aging

  title={Klotho protein deficiency and aging},
  author={H. Manya and K. Akasaka-Manya and T. Endo},
  journal={Geriatrics & Gerontology International},
  • H. Manya, K. Akasaka-Manya, T. Endo
  • Published 2010
  • Medicine
  • Geriatrics & Gerontology International
  • Aging is inevitable; however, the molecular mechanism of aging has not been fully elucidated. Investigations into aging are facing difficulties because aging is influenced by complex factors such as circumstances, living habits and genetic background. Recently, a variety of animals, such as Caenorhabditis elegans, Drosophila and mice, that have aberrations in their lifespan, have been investigated and a large number of genes related to aging have been found, one of which is α‐klotho. The… CONTINUE READING
    29 Citations

    Topics from this paper

    Significance of the anti-aging protein Klotho
    • 31
    Aging biology: a new frontier for drug discovery
    • 16
    Genetics of aging and longevity
    • 7
    • PDF
    Klotho suppresses the inflammatory responses and ameliorates cardiac dysfunction in aging endotoxemic mice
    • 29
    • PDF
    αKlotho and Chronic Kidney Disease.
    • 95
    Klotho Mice: A Novel Wound Model of Aged Skin
    • 6
    Aging and uremia: Is there cellular and molecular crossover?
    • 23
    Klotho protein diminishes endothelial apoptosis and senescence via a mitogen‐activated kinase pathway
    • 60


    Klotho Protein Deficiency Leads to Overactivation of μ-Calpain*
    • 59
    • PDF
    Association of human aging with a functional variant of klotho
    • 397
    • PDF
    Mutation of the mouse klotho gene leads to a syndrome resembling ageing
    • 2,697
    Suppression of Aging in Mice by the Hormone Klotho
    • 1,354
    • PDF
    Regulation of Oxidative Stress by the Anti-aging Hormone Klotho*♦
    • 505
    • PDF
    Klotho Gene Polymorphisms Associated With Bone Density of Aged Postmenopausal Women
    • K. Kawano, N. Ogata, +12 authors H. Kawaguchi
    • Biology, Medicine
    • Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
    • 2002
    • 170
    α-Klotho as a Regulator of Calcium Homeostasis
    • 306
    Klotho Gene Polymorphism and Male Bone Mass
    • 34