Klotho protein deficiency and aging

@article{Manya2010KlothoPD,
  title={Klotho protein deficiency and aging},
  author={Hiroshi Manya and Keiko Akasaka-Manya and Tamao Endo},
  journal={Geriatrics \& Gerontology International},
  year={2010},
  volume={10}
}
Aging is inevitable; however, the molecular mechanism of aging has not been fully elucidated. Investigations into aging are facing difficulties because aging is influenced by complex factors such as circumstances, living habits and genetic background. Recently, a variety of animals, such as Caenorhabditis elegans, Drosophila and mice, that have aberrations in their lifespan, have been investigated and a large number of genes related to aging have been found, one of which is α‐klotho. The… 
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References

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Klotho Protein Deficiency Leads to Overactivation of μ-Calpain*
TLDR
It is reported that in homozygotes for the klotho mutation (kl −/−), αII-spectrin is highly cleaved, even before the occurrence of aging symptoms such as calcification and arteriosclerosis, and such deterioration may trigger renal abnormalities inkl−/− mice and aged mice, but Klotho protein may suppress these processes.
Association of human aging with a functional variant of klotho
TLDR
The results suggest that the KL-VS allele influences the trafficking and catalytic activity of klotho, and that variation in klOTHo function contributes to heterogeneity in the onset and severity of human age-related phenotypes.
Mutation of the mouse klotho gene leads to a syndrome resembling ageing
TLDR
A new gene, termed klotho, has been identified that is involved in the suppression of several ageing phenotypes in the mouse, and may function as part of a signalling pathway that regulates ageing in vivo and morbidity in age-related diseases.
Suppression of Aging in Mice by the Hormone Klotho
TLDR
It is shown that overexpression of Klotho in mice extends life span and it is suggested that Klotha-mediated inhibition of insulin and IGF1 signaling contributes to its anti-aging properties.
Immunohistochemical localization of Klotho protein in brain, kidney, and reproductive organs of mice.
Klotho mutant mouse (kl-/-), a mouse model for human aging, exhibits various phenotypes in a wide range of organs including arteriosclerosis, neural degeneration, skin and gonadal atrophy, pulmonary
Regulation of Oxidative Stress by the Anti-aging Hormone Klotho*♦
TLDR
It is shown that Klotho protein increases resistance to oxidative stress at the cellular and organismal level in mammals and potentially contributes to the anti-aging properties of klotho.
Klotho protein activates the PKC pathway in the kidney and testis and suppresses 25-hydroxyvitamin D3 1α-hydroxylase gene expression
TLDR
The data suggest that calcium regulation through 25-hydroxyvitamin D3 1α-hydroxylase by Klotho depends on non-cAMP and a non-PKC pathway and that the Klotha protein may have different signaling pathways, depending on the Klothso gene expression in different cells and organs.
Klotho Gene Polymorphisms Associated With Bone Density of Aged Postmenopausal Women
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TLDR
Results indicate that the klotho gene may be involved in the pathophysiology of bone loss with aging in humans by examining the association between klOTHo gene polymorphisms and bone density in two genetically distinct racial populations: the white and the Japanese.
α-Klotho as a Regulator of Calcium Homeostasis
TLDR
Fundamental roles of α-Kl in the regulation of calcium metabolism are revealed and the increased Na+ gradient created by Na+,K+-ATPase activity might drive the transepithelial transport of Ca2+ in cooperation with ion channels and transporters in the choroid plexus and the kidney.
Klotho Gene Polymorphism and Male Bone Mass
TLDR
It is suggested that allelic variants of Klotho constitute one of the genetic factors influencing BMD in male adults, as well as the aging process, in young and middle-aged men.
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