Klotho protects against mouse renal fibrosis by inhibiting Wnt signaling.

  title={Klotho protects against mouse renal fibrosis by inhibiting Wnt signaling.},
  author={Minoru Satoh and Hajime Nagasu and Yoshitaka Morita and T. P. Yamaguchi and Yashpal S. Kanwar and Naoki Kashihara},
  journal={American journal of physiology. Renal physiology},
  volume={303 12},
Augmented Wnt signaling has been implicated in many fibrotic diseases including obstructive nephropathy. Soluble form Klotho has been reported to function as a secreted Wnt antagonist. In this study, we tested whether Klotho protein could reduce renal fibrosis by inhibition of Wnt signaling. Transgenic mice that overexpressed Klotho, wild-type mice, and Klotho hetero mutant mice underwent unilateral ureteral obstruction (UUO). In some Klotho hetero mutant mice, Klotho-encoding plasmid was… CONTINUE READING
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