Klotho insufficiency causes decrease of ribosomal RNA gene transcription activity, cytoplasmic RNA and rough ER in the spinal anterior horn cells

@article{Anamizu2004KlothoIC,
  title={Klotho insufficiency causes decrease of ribosomal RNA gene transcription activity, cytoplasmic RNA and rough ER in the spinal anterior horn cells},
  author={Yorito Anamizu and Hiroshi Kawaguchi and Atsushi Seichi and Shinji Yamaguchi and Emiko Kawakami and Naotoshi Kanda and Shiro Matsubara and Makoto Kuro-O and Yoichi Nabeshima and Kozo Nakamura and Kiyomitsu Oyanagi},
  journal={Acta Neuropathologica},
  year={2004},
  volume={109},
  pages={457-466}
}
The klotho gene was identified in 1997 as the gene whose severe insufficiency (kl/kl) causes a syndrome resembling human aging, such as osteoporosis, arteriosclerosis, gonadal atrophy, emphysema, and short life span in a mouse strain. Regarding the gait disturbance reported in kl/kl mice, the present study examined the spinal cord of kl/kl mice, and revealed decreases in the number of large anterior horn cells (AHCs), the amount of cytoplasmic RNA, the number of ribosomes and rough endoplasmic… CONTINUE READING

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