Klotho inhibits growth and promotes apoptosis in human lung cancer cell line A549

@inproceedings{Chen2010KlothoIG,
  title={Klotho inhibits growth and promotes apoptosis in human lung cancer cell line A549},
  author={Bo Chen and Xueli Wang and Weihong Zhao and Jianqing Wu},
  booktitle={Journal of experimental & clinical cancer research : CR},
  year={2010}
}
BACKGROUND Klotho, as a new anti-aging gene, can shed into circulation and act as a multi-functional humoral factor that influences multiple biological processes. Recently, published studies suggest that klotho can also serve as a potential tumor suppressor. The aim of this study is to investigate the effects and possible mechanisms of action of klotho in human lung cancer cell line A549. METHODS In this study, plasmids encoding klotho or klotho specific shRNAs were constructed to overexpress… CONTINUE READING

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