Klotho converts canonical FGF receptor into a specific receptor for FGF23

@article{Urakawa2006KlothoCC,
  title={Klotho converts canonical FGF receptor into a specific receptor for FGF23},
  author={Itaru Urakawa and Yuji Yamazaki and Takashi Shimada and Kousuke Iijima and Hisashi Hasegawa and Katsuya Okawa and Toshiro Fujita and Seiji Fukumoto and Takeyoshi Yamashita},
  journal={Nature},
  year={2006},
  volume={444},
  pages={770-774}
}
FGF23 is a unique member of the fibroblast growth factor (FGF) family because it acts as a hormone that derives from bone and regulates kidney functions, whereas most other family members are thought to regulate various cell functions at a local level. The renotropic activity of circulating FGF23 indicates the possible presence of an FGF23-specific receptor in the kidney. Here we show that a previously undescribed receptor conversion by Klotho, a senescence-related molecule, generates the FGF23… 

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  • 2017
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...

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