Klotho as a regulator of oxidative stress and senescence

@inproceedings{Kuroo2008KlothoAA,
  title={Klotho as a regulator of oxidative stress and senescence},
  author={Makoto Kuro-o},
  booktitle={Biological chemistry},
  year={2008}
}
Abstract The klotho gene functions as an aging-suppressor gene that extends life span when overexpressed and accelerates aging-like phenotypes when disrupted in mice. The klotho gene encodes a single-pass transmembrane protein that binds to multiple fibroblast growth factor (FGF) receptors and functions as a co-receptor for FGF23, a bone-derived hormone that suppresses phosphate reabsorption and vitamin D biosynthesis in the kidney. In addition, the extracellular domain of Klotho protein is… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 76 REFERENCES

Regulation of oxidative stress by the anti-aging hormone klotho.

VIEW 7 EXCERPTS
HIGHLY INFLUENTIAL

Suppression of aging in mice by the hormone Klotho.

VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Mutation of the mouse klotho gene leads to a syndrome resembling ageing

  • M. Kuro-o, Y. Matsumura, +7 authors E Kume
  • Nature 390,
  • 1997
VIEW 17 EXCERPTS
HIGHLY INFLUENTIAL

BetaKlotho is required for metabolic activity of fibroblast growth factor 21.

VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

Co-receptor requirements for fibroblast growth factor-19 signaling.

VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

Liver-specific activities of FGF19 require Klotho beta.

VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL