Klotho as a regulator of oxidative stress and senescence.

  title={Klotho as a regulator of oxidative stress and senescence.},
  author={Makoto Kuro-O},
  journal={Biological chemistry},
  volume={389 3},
The klotho gene functions as an aging-suppressor gene that extends life span when overexpressed and accelerates aging-like phenotypes when disrupted in mice. The klotho gene encodes a single-pass transmembrane protein that binds to multiple fibroblast growth factor (FGF) receptors and functions as a co-receptor for FGF23, a bone-derived hormone that suppresses phosphate reabsorption and vitamin D biosynthesis in the kidney. In addition, the extracellular domain of Klotho protein is shed and… CONTINUE READING