Klotho ameliorates chemically induced endoplasmic reticulum (ER) stress signaling.

  title={Klotho ameliorates chemically induced endoplasmic reticulum (ER) stress signaling.},
  author={Srijita Banerjee and Yanhua Zhao and Partha S. Sarkar and Kevin P. Rosenblatt and Ronald G. Tilton and Sanjeev Choudhary},
  journal={Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology},
  volume={31 4-5},
BACKGROUND Both endoplasmic reticulum (ER) stress, a fundamental cell response associated with stress-initiated unfolded protein response (UPR), and loss of Klotho, an anti-aging hormone linked to NF-κB-induced inflammation, occur in chronic metabolic diseases such as obesity and type 2 diabetes. We investigated if the loss of Klotho is causally linked to increased ER stress. METHODS We treated human renal epithelial HK-2, alveolar epithelial A549, HEK293, and SH-SH-SY5Y neuroblastoma cells… CONTINUE READING
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