Klotho Sensitivity of the Neuronal Excitatory Amino Acid Transporters EAAT3 and EAAT4

@inproceedings{Almilaji2013KlothoSO,
  title={Klotho Sensitivity of the Neuronal Excitatory Amino Acid Transporters EAAT3 and EAAT4},
  author={Ahmad Almilaji and Carlos German Mu{\~n}oz and Tatsiana Pakladok and Ioana S Alesutan and Martina Feger and Michael F{\"o}ller and Undine E. Lang and Ekaterina Shumilina and Florian Lang},
  booktitle={PloS one},
  year={2013}
}
Klotho, a transmembrane protein, which can be cleaved off as β-glucuronidase and hormone, is released in both, kidney and choroid plexus and encountered in blood and cerebrospinal fluid. Klotho deficiency leads to early appearance of age-related disorders and premature death. Klotho may modify transport by inhibiting 1,25(OH)2D3 formation or by directly affecting channel and carrier proteins. The present study explored whether Klotho influences the activity of the Na(+)-coupled excitatory amino… CONTINUE READING

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Electrogenic excitatory amino acid transport was determined as L - glutamate - induced current ( Iglu ) in two electrode voltage clamp experiments . EAAT3 and
Electrogenic excitatory amino acid transport was determined as L - glutamate - induced current ( Iglu ) in two electrode voltage clamp experiments . EAAT3 and
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