Klotho Regulates 14-3-3ζ Monomerization and Binding to the ASK1 Signaling Complex in Response to Oxidative Stress

@inproceedings{Brobey2015KlothoR1,
  title={Klotho Regulates 14-3-3ζ Monomerization and Binding to the ASK1 Signaling Complex in Response to Oxidative Stress},
  author={Reynolds K B Brobey and Mehdi Dheghani and Philip P. Foster and Makoto Kuro-O and Kevin P. Rosenblatt and Hemant K. Paudel},
  booktitle={PloS one},
  year={2015}
}
The reactive oxygen species (ROS)-sensitive apoptosis signal-regulating kinase 1 (ASK1) signaling complex is a key regulator of p38 MAPK activity, a major modulator of stress-associated with aging disorders. We recently reported that the ratio of free ASK1 to the complex-bound ASK1 is significantly decreased in Klotho-responsive manner and that Klotho-deficient tissues have elevated levels of free ASK1 which coincides with increased oxidative stress. Here, we tested the hypothesis that: 1… CONTINUE READING
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