Klotho Protects Against Indoxyl Sulphate-Induced Myocardial Hypertrophy.

  title={Klotho Protects Against Indoxyl Sulphate-Induced Myocardial Hypertrophy.},
  author={Ke Yang and Cheng Wang and Ling Nie and Xiaohui Zhao and Jun Gu and Xu Guan and Song Wang and Tangli Xiao and Xinli Xu and Ting He and Xuefeng Xia and Junping Wang and Jinghong Zhao},
  journal={Journal of the American Society of Nephrology : JASN},
  volume={26 10},
Left ventricular hypertrophy (LVH) is a common complication in patients with CKD and an independent risk factor for death. Changes in the levels of uremic solutes or Klotho have been reported to be related to CKD, whereas the relationships between these factors and CKD-associated LVH remain unclear. Here, we investigated the interaction between Klotho and indoxyl sulfate (IS), a typical uremic solute, in CKD-associated LVH. In a survey of 86 patients with CKD, a negative relationship was found… CONTINUE READING
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