Klinefelter syndrome in adolescence: onset of puberty is associated with accelerated germ cell depletion.

@article{Wikstrm2004KlinefelterSI,
  title={Klinefelter syndrome in adolescence: onset of puberty is associated with accelerated germ cell depletion.},
  author={Anne M Wikstr{\"o}m and Taneli Raivio and Faruk Hadziselimovic and Sakari Wikstr{\"o}m and Timo Tuuri and Leo Dunkel},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2004},
  volume={89 5},
  pages={2263-70}
}
The process of germ cell depletion in patients with Klinefelter syndrome (KS) is incompletely characterized. In the current work, we evaluated the presence of germ cells in adolescent boys with KS for possible future use in assisted reproduction techniques. Fourteen nonmosaic 47,XXY boys (aged 10-14 yr) were enrolled. Every fourth month their puberty was staged, and serum was obtained for hormone analyses. Each boy underwent a single testicular biopsy. Biopsy specimens of seven peripubertal… CONTINUE READING

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