Klf5 maintains the balance of primitive endoderm versus epiblast specification during mouse embryonic development by suppression of Fgf4.

@article{Azami2017Klf5MT,
  title={Klf5 maintains the balance of primitive endoderm versus epiblast specification during mouse embryonic development by suppression of Fgf4.},
  author={Takuya Azami and Tsuyoshi Waku and Ken Matsumoto and Hyojung Jeon and Masafumi Muratani and Akihiro Kawashima and Jun Yanagisawa and Ichiro Manabe and Ryozo Nagai and Tilo Kunath and Tomonori Nakamura and Kazuki Kurimoto and Mitinori Saitou and Satoru Takahashi and Masatsugu Ema},
  journal={Development},
  year={2017},
  volume={144 20},
  pages={3706-3718}
}
The inner cell mass of the mouse blastocyst gives rise to the pluripotent epiblast (EPI), which forms the embryo proper, and the primitive endoderm (PrE), which forms extra-embryonic yolk sac tissues. All inner cells coexpress lineage markers such as Nanog and Gata6 at embryonic day (E) 3.25, and the EPI and PrE precursor cells eventually segregate to… CONTINUE READING