Klf4 reverts developmentally programmed restriction of ground state pluripotency.

  title={Klf4 reverts developmentally programmed restriction of ground state pluripotency.},
  author={Ge Guo and Jian Yang and Jennifer Nichols and John E. Simon Hall and Isobel Eyres and William H. Mansfield and Austin G. Smith},
  volume={136 7},
Mouse embryonic stem (ES) cells derived from pluripotent early epiblast contribute functionally differentiated progeny to all foetal lineages of chimaeras. By contrast, epistem cell (EpiSC) lines from post-implantation epithelialised epiblast are unable to colonise the embryo even though they express the core pluripotency genes Oct4, Sox2 and Nanog. We examined interconversion between these two cell types. ES cells can readily become EpiSCs in response to growth factor cues. By contrast, EpiSCs… CONTINUE READING
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