Klf2 is an essential factor that sustains ground state pluripotency.

  title={Klf2 is an essential factor that sustains ground state pluripotency.},
  author={Jia-Chi Yeo and Jianming Jiang and Zi-Ying Tan and Guo-Rong Yim and Jia-Hui Ng and Jonathan G{\"o}ke and Petra Kraus and Hongqing Liang and Kevin Gonzales and Han-Chung Chong and Cheng-Peow Tan and Yee-Siang Lim and Nguan-Soon Tan and Thomas Lufkin and Huck H. Ng},
  journal={Cell stem cell},
  volume={14 6},
The maintenance of mouse embryonic stem cells (mESCs) requires LIF and serum. However, a pluripotent "ground state," bearing resemblance to preimplantation mouse epiblasts, can be established through dual inhibition (2i) of both prodifferentiation Mek/Erk and Gsk3/Tcf3 pathways. While Gsk3 inhibition has been attributed to the transcriptional derepression of Esrrb, the molecular mechanism mediated by Mek inhibition remains unclear. In this study, we show that Krüppel-like factor 2 (Klf2) is… CONTINUE READING
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