Klebsiella pneumoniae outer membrane porins OmpK35 and OmpK36 play roles in both antimicrobial resistance and virulence.

@article{Tsai2011KlebsiellaPO,
  title={Klebsiella pneumoniae outer membrane porins OmpK35 and OmpK36 play roles in both antimicrobial resistance and virulence.},
  author={Y H Tsai and C. Victor Fung and J Lin and Jiun-Han Chen and F -Y. Chang and T L Chen and L. Kristopher Siu},
  journal={Antimicrobial agents and chemotherapy},
  year={2011},
  volume={55 4},
  pages={1485-93}
}
OmpK35 and OmpK36 are the major outer membrane porins of Klebsiella pneumoniae. In this study, a virulent clinical isolate was selected to study the role of these two porins in antimicrobial resistance and virulence. The single deletion of ompK36 (ΔompK36) resulted in MIC shifts of cefazolin, cephalothin, and cefoxitin from susceptible to resistant, while the single deletion of ompK35 (ΔompK35) had no significant effect. A double deletion of ompK35 and ompK36 (ΔompK35/36) further increased… CONTINUE READING