Klebsiella pneumoniae glycoprotein RU-41740 enhances resistance of mice against Mycoplasma arthritidis-induced arthritis.

@article{Kaklamani1991KlebsiellaPG,
  title={Klebsiella pneumoniae glycoprotein RU-41740 enhances resistance of mice against Mycoplasma arthritidis-induced arthritis.},
  author={Evangelia Kaklamani and Yvonni Koumantaki and D. Karalis and M. Rommain and Pierre Smets and P. Kaklamanis and C. Caroline Blackwell and Donald Mackay Weir},
  journal={FEMS microbiology immunology},
  year={1991},
  volume={3 4},
  pages={
          205-10
        }
}
The effect of a purified glycoprotein extract from Klebsiella pneumoniae with non-specific immunostimulating properties (RU 41740) on the development and course of mycoplasma arthritis was investigated. Male A/J mice aged 2-3 months were given RU-41740 either intraperitoneally (i.p.) or orally prior to injection with Mycoplasma arthritidis. RU-41740 injected i.p. at 0.1 mg kg-1 or given orally at 1 mg kg-1 prior to the infection and subsequently on alternate days enhanced the resistance of mice… 
1 Citations
The effect of Mycoplasma arthritidis infection on the kinetics of colloidal carbon clearance in mice.
TLDR
The early depressive effect on phagocytic activity may be related to superantigen activity with the production of mediators such as macrophage deactivating factor, which might bring about the stimulation of autoreactive clones of T and B cells and be responsible for the chronic arthritis that developed in the mycoplasma treated mice.

References

SHOWING 1-10 OF 12 REFERENCES
Factors Influencing the Susceptibility of Mice to Mycoplasma arthritidis
TLDR
Concentrated broth constituents markedly enhanced the development of abscesses after subcutaneous injection of Mycoplasma arthritidis, and Comparative studies using different mouse strains showed that DBA mice were the most susceptible and BALB/c and C57BL micewere the most resistant to infection by M. arhritidis.
Chronic Proliferative Arthritis of Mice Induced by Mycoplasma arthritidis I. Induction of Disease and Histopathological Characteristics
TLDR
The clinical course and histopathological characteristics of the chronic phase of mouse arthritis induced by M. arthritidis closely resembled those of rheumatoid arthritis of man.
Immunosuppressive properties of the Mycoplasma arthritidis T-cell mitogen in vivo: inhibition of proliferative responses to T-cell mitogens
TLDR
It is hypothesize that MAM may play a role in M. arthritidis-mediated disease by both its inflammatory and immunosuppressive properties as well as major histocompatibility complex restrictions.
The immunosuppressive effect of mycoplasma infection. I. Effect on the humoral and cellular response.
TLDR
It was concluded that immunosuppression might be the result of the effect of M. arthritidis on a particular population of cells.
Persistence of Mycoplasma hominis after therapy: importance of tetracycline resistance and of coexisting vaginal flora.
TLDR
The results suggest that colonization of the vagina with M. hominis is partly dependent on other components of the vaginal microbial flora, and tetracycline resistance in treatment failure was not defined.
In vitro modulation of human monocytes functions by RU 41740 (Biostim).
The effect of RU 41.740, an immune modulating compound, in the prevention of acute exacerbations in patients with chronic bronchitis.
TLDR
A significant (p = 0.005) reduction in the number of acute exacerbations was observed in the patients treated with Biostim 2 mg/day, whereas no effect was seen in the placebo or 8mg/day group.
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