Klebsiella pneumoniae glycoprotein RU-41740 enhances resistance of mice against Mycoplasma arthritidis-induced arthritis.

@article{Kaklamani1991KlebsiellaPG,
  title={Klebsiella pneumoniae glycoprotein RU-41740 enhances resistance of mice against Mycoplasma arthritidis-induced arthritis.},
  author={Evangelia Kaklamani and Yvonni Koumantaki and D. Karalis and M. Rommain and Pierre Smets and P. Kaklamanis and C. Caroline Blackwell and Donald Mackay Weir},
  journal={FEMS microbiology immunology},
  year={1991},
  volume={3 4},
  pages={
          205-10
        }
}
The effect of a purified glycoprotein extract from Klebsiella pneumoniae with non-specific immunostimulating properties (RU 41740) on the development and course of mycoplasma arthritis was investigated. Male A/J mice aged 2-3 months were given RU-41740 either intraperitoneally (i.p.) or orally prior to injection with Mycoplasma arthritidis. RU-41740 injected i.p. at 0.1 mg kg-1 or given orally at 1 mg kg-1 prior to the infection and subsequently on alternate days enhanced the resistance of mice… 
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The effect of Mycoplasma arthritidis infection on the kinetics of colloidal carbon clearance in mice.
TLDR
The early depressive effect on phagocytic activity may be related to superantigen activity with the production of mediators such as macrophage deactivating factor, which might bring about the stimulation of autoreactive clones of T and B cells and be responsible for the chronic arthritis that developed in the mycoplasma treated mice.

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