KlRHO1 and KlPKC1 are essential for cell integrity signalling in Kluyveromyces lactis.

@article{Rodicio2006KlRHO1AK,
  title={KlRHO1 and KlPKC1 are essential for cell integrity signalling in Kluyveromyces lactis.},
  author={Rosaura Rodicio and Sabrina Koch and H. -J. Schmitz and J{\"u}rgen J. Heinisch},
  journal={Microbiology},
  year={2006},
  volume={152 Pt 9},
  pages={2635-49}
}
Cell integrity in yeasts is ensured by a rigid cell wall whose synthesis is triggered by a MAP kinase-mediated signal-transduction cascade. Upstream regulatory components of this pathway in Saccharomyces cerevisiae involve a single protein kinase C, which is regulated by interaction with the small GTPase Rho1. Here, two genes were isolated which encode these proteins from Kluyveromyces lactis (KlPKC1 and KlRHO1). Sequencing showed ORFs which encode proteins of 1,161 and 208 amino acids… CONTINUE READING