Kit signaling is required for development of coordinated motility patterns in zebrafish gastrointestinal tract.

@article{Rich2013KitSI,
  title={Kit signaling is required for development of coordinated motility patterns in zebrafish gastrointestinal tract.},
  author={Adam Rich and Scott A. Gordon and Chris L Brown and Simon J. Gibbons and Katherine Schaefer and Grant Hennig and Gianrico Farrugia},
  journal={Zebrafish},
  year={2013},
  volume={10 2},
  pages={154-60}
}
Interstitial cells of Cajal (ICC) provide a pacemaker signal for coordinated motility patterns in the mammalian gastrointestinal (GI) tract. Kit signaling is required for development and maintenance of ICC, and these cells can be identified by Kit-like immunoreactivity. The zebrafish GI tract has two distinct ICC networks similar to mammals, suggesting a similar role in the generation of GI motility; however, a functional role for Kit-positive cells in zebrafish has not been determined… CONTINUE READING
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