Kit regulates HSC engraftment across the human-mouse species barrier.

  title={Kit regulates HSC engraftment across the human-mouse species barrier.},
  author={Kadriye Nehir Cosgun and Susann Rahmig and Nicole Mende and S{\"o}ren Reinke and I. Forftrat Hauber and Carola Sch{\"a}fer and Anke Petzold and Henry Weisbach and Gordon F Heidkamp and Ariawan Purbojo and Robert Anton Cesnjevar and Alexander Platz and Martin Bornhaeuser and Marc Schmitz and Diana Dudziak and Joachim Hauber and Joerg Kirberg and Claudia Waskow},
  journal={Cell stem cell},
  volume={15 2},
In-depth analysis of the cellular and molecular mechanisms regulating human HSC function will require a surrogate host that supports robust maintenance of transplanted human HSCs in vivo, but the currently available options are problematic. Previously we showed that mutations in the Kit receptor enhance engraftment of transplanted HSCs in the mouse. To generate an improved model for human HSC transplantation and analysis, we developed immune-deficient mouse strains containing Kit mutations. We… CONTINUE READING
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