Kit ligand and Il7 differentially regulate Peyer's patch and lymph node development.

@article{Chappaz2010KitLA,
  title={Kit ligand and Il7 differentially regulate Peyer's patch and lymph node development.},
  author={Stephane Chappaz and Claudia G{\"a}rtner and Hans-Reimer Rodewald and Daniela Finke},
  journal={Journal of immunology},
  year={2010},
  volume={185 6},
  pages={3514-9}
}
Hematopoietic lymphoid tissue inducer (LTi) cells initiate lymph node (LN) and Peyer's patch (PP) development during fetal life by inducing the differentiation of mesenchymal organizer cells. The growth factor signals underlying LTi cell development and LN and PP organogenesis remain poorly understood. LTi cells express the Il7r and the receptor tyrosine kinase Kit, whereas organizer cells express their cognate ligands. To determine the relative significance of Il7 and Kit signaling in LTi cell… CONTINUE READING