Kit and foxd3 genetically interact to regulate melanophore survival in zebrafish.

@article{Cooper2009KitAF,
  title={Kit and foxd3 genetically interact to regulate melanophore survival in zebrafish.},
  author={Cynthia D Cooper and Tor H. Linbo and David W. Raible},
  journal={Developmental dynamics : an official publication of the American Association of Anatomists},
  year={2009},
  volume={238 4},
  pages={875-86}
}
We have investigated the role of foxd3 activity in conjunction with signaling by the kit tyrosine kinase receptor in zebrafish black pigment cell (melanophore) development. As loss-of-function of these molecules individually has distinct effects on melanophore number, we have examined the phenotype of double mutants. Individuals with a null mutation in kit have fewer melanophores than wild-type, with cells lost through death. When kit mutants are injected with foxd3 antisense morpholino… CONTINUE READING